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Case Report
12.
Multiple organs metastatic mesothelioma in a white
tiger: A case report -
Debasish Behera, Ashabaree Samal
Vet World. 2012; 5(9): 568-570
doi:
10.5455/vetworld.2012.5
68-570
Abstract
Aim:
An attempt has been made to know the cause of the
death of the female white tiger, who was considered
as Queen of the Zoo and has given birth of 22 white
tigers in her life time.
Materials and Methods:
Complete clinical examinations were carried out
such as heart rate, respiratory rate and body
temperature and haematology etc. After death, the
detailed and complete post mortem examination was
performed and representative tissue samples were
processed for histological investigation by formalin
fixation and paraffin embedding technique as
described by Luna.
Results: Mesothelioma is a
form of neoplasm having mesenchymal cell origin. In
this investigation clinical signs were recorded and
Clinical examination revealed no abnormality except
anaemia with Neutrophilia and Lymphocytosis. At
necropsy, the thoracic and abdominal cavities
contained a large amount of serosanguineous and
blood tinged fluid. The peritoneum showed Multiple,
grayish – white nodules of varying size of 1 to 2cm
diameter were scattered throughout surfaces.
Neoplastic growths were also found in the parenchyma
of the liver, lungs, spleen, intestine and
mesenteric, tracheobronchial, mediastinal lymph
nodes. Microscopic examination revealed Pleural and
peritoneal surfaces were markedly thickened by
multiple layers of neoplastic mesothelial cells with
well supported by collagenous connective tissues.
The neoplastic cells of different organs (lungs and
liver) showed larger vesicular nuclei, prominent
nucleoli and neoplastic cell emboli.
Conclusion:
Gross lesions and histopathological studies were
suggestive for malignant mesothelioma and originated
from the peritoneum with secondary metastasis to
other organs and lymphnode.
Keywords:
Mesothelioma, metastasis, neoplastic cells,
pathomorphology, white tiger
